What is the prevalence of functionally significant genetic variants in LQTS genes among cases diagnosed as SIDS?
Nearly 10% of SIDS cases carry functionally significant LQTS gene variants, suggesting sudden arrhythmic death is a major contributor and supporting the potential role of infant ECG screening.
We demonstrated that 9.5% of cases diagnosed as SIDS carry functionally significant genetic variants in LQTS genes. The present study demonstrates that sudden arrhythmic death is an important contributor to SIDS. As these variants likely modify ventricular repolarization and QT interval duration, our results support the debated concept that an ECG would probably identify most infants at risk for sudden death due to LQTS either in infancy or later on in life.
Arnestad et al. (Tue,) studied this question.