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What are the genetic susceptibility loci associated with spontaneous coronary artery dissection?
What are the genetic susceptibility loci associated with spontaneous coronary artery dissection?
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The identification of 5 genetic risk loci for SCAD suggests a shared genetic architecture with extracoronary arteriopathies and an inverse allelic susceptibility compared to atherosclerotic coronary artery disease.
This study revealed 5 replicated risk loci and positional candidate genes for SCAD, most of which are associated with extracoronary arteriopathies. Moreover, the alternate alleles of 3 SNVs have been previously associated with atherosclerotic coronary artery disease, further implicating allelic susceptibility to coronary artery atherosclerosis vs dissection.
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Turley et al. (2020) studied this question.
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