Why the study?
Does karyotype complexity or ploidy predict overall and relapse-free survival in patients with Ewing's sarcoma family tumors?
Population
88 patients with primary Ewing's sarcoma family tumors (ESFT) and a rearrangement of 22q12
Comparison
Presence of complex karyotype, chromosome number… vs Absence of these cytogenetic abnormalities
Design
Cohort
Authors
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Complex karyotype should not yet alter Ewing sarcoma management; extends prognostic observations but leaves open prospective validation for therapy guidance.
Does karyotype complexity or ploidy predict overall and relapse-free survival in patients with Ewing's sarcoma family tumors?
Karyotype complexity and specific chromosomal abnormalities like trisomy 20 are powerful independent predictors of poor prognosis in Ewing's sarcoma family tumors.
Roberts et al. (2007) studied this question.
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