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August 28, 1998Science9,028 citations

Mitochondria and Apoptosis

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DGDouglas R. GreenJRJohn C. Reed

Key Points

  • Investigate the role of mitochondria in apoptosis and the signaling pathways involved in cell death.
  • Analyze mitochondrial events such as caspase activator release and changes in electron transport.
  • Examine the loss of mitochondrial transmembrane potential and its relation to cell death.
  • Identify the functions of pro- and antiapoptotic Bcl-2 family proteins.
  • Mitochondria release caspase activators like cytochrome c, initiating apoptosis.
  • Alterations in mitochondrial transmembrane potential correlate with cell death progression.
  • Both pro- and antiapoptotic Bcl-2 proteins play crucial roles in regulating mitochondrial functions.

Abstract

A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.

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Cite This Study

Green et al. (1998) studied this question.

synapsesocial.com/papers/69d837b98c03fbaff8bee18fhttps://doi.org/10.1126/science.281.5381.1309
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