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Two-in-one: Me3 SiCF2 Br is an efficient difluorocarbene source and is compatible with both neutral and aqueous basic conditions. Bromide-ion-initiated 2+1 cycloaddition with alkenes/alkynes and hydroxide ion promoted α-addition with (thio)phenols, (thio)alcohols, sulfinates, heterocyclic amines, and H-phosphine oxides give the corresponding gem-difluorinated compounds with broad functional-group tolerance.
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Lingchun Li
Shanghai Institute of Organic Chemistry
Fei Wang
Nankai University
Chuanfa Ni
Shanghai Institute of Organic Chemistry
Angewandte Chemie International Edition
Chinese Academy of Sciences
Shanghai Institute of Organic Chemistry
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Li et al. (Thu,) studied this question.
synapsesocial.com/papers/69d83b20617ce96c42ae356a — DOI: https://doi.org/10.1002/anie.201306703