Oxidative Coupling in Complexity Building Transforms

Since many synthetic targets in organic chemistry are larger, more functionalized, and more oxidized than the starting inputs used, methods that unite fragments with an increase in oxidation state possess inherent efficiencies. Thus, the potential for complexity building transforms by union of activated or unactivated C-H, N-H, or O-H centers is considerable, and the challenge lies in how to obtain selective reactions from any two of these centers.