May 1, 2007Genes & DevelopmentOpen Access

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

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Why the study?

Does Tbx3 regulate the specification and formation of the sinoatrial node in mice?

Population

Mice models (Tbx3-deficient and ectopic Tbx3 expression)

Comparison

Tbx3 deficiency and ectopic expression of Tbx3 vs Wild-type/control mice (implied)

Design

Preclinical

Authors

WHWillem M.H. HoogaarsUniversity Medical Center Groningen AEAngela EngelCombined Ophthalmic Research Rotterdam JBJanynke F. BronsAmsterdam UMC Location University of Amsterdam

Discussion

Member takes

Implication

Tbx3 dictates murine SAN identity; hypothesis-generating for arrhythmia mechanisms, clinical translation remains open.

Structured PICO

Does Tbx3 regulate the specification and formation of the sinoatrial node in mice?

Population

Mice models (Tbx3-deficient and ectopic Tbx3 expression)

Intervention

Tbx3 deficiency and ectopic expression of Tbx3

Comparator

Wild-type/control mice (implied)

Outcome

Sinoatrial node specification, gene expression program, and pacemaker phenotypesurrogate

Tbx3 is a critical transcriptional regulator that controls the sinoatrial node gene program and can impose pacemaker function on atrial tissue.

Cite This Study

Hoogaars et al. (2007) studied this question.

synapsesocial.com/papers/69d842d2d56ca42147d17e91 https://doi.org/10.1101/gad.416007

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Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider