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May 21, 2009SHILAP Revista de lepidopterologíaOpen Access

The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines

Hang Joo Cho Sin Young Kim Kee Hwan Kim Won Kyung Kang Ji‐il Kim Seong Tack Oh Jeong Soo Kim Chang Hyeok An

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Abstract

In conclusion, 5-aza-DC and SB can enhance radiosensitivity in both MCF-7 and RKO cell lines. The combination effect of a demethylating agent and an HDAC inhibitor is more effective than that of single agent treatment in both breast and colon cancer cell lines.

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Cho et al. (2009) studied this question.

synapsesocial.com/papers/69d843dbf4e559c61eae3296 https://doi.org/10.1186/1477-7819-7-49

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1DNA demethylation and histone deacetylation inhibition co‐operate to re‐express estrogen receptor beta and induce apoptosis in prostate cancer cell‐linesOriginal Research · 2007 · 121 citations
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