June 7, 2006BMC Health Services Research169 citationsOpen Access
Using the net benefit regression framework to construct cost-effectiveness acceptability curves: an example using data from a trial of external loop recorders versus Holter monitoring for ambulatory monitoring of "community acquired" syncope
Structured PICO
Are external loop recorders more cost-effective than Holter monitoring for ambulatory monitoring of "community acquired" syncope?
P
Population
Patients with "community acquired" syncope
I
Intervention
External loop recorders
C
Comparator
Holter monitoring
O
Outcome
Cost-effectiveness
The net benefit regression framework provides a straightforward method for constructing cost-effectiveness acceptability curves in clinical trials.
Abstract
The NBRF is straightforward to use and interpret. The resulting uncertainty surrounding the regression coefficient relates to the CEAC. When the link from the regression's p-value to the probability of cost-effectiveness is tentative, bootstrapping may be used.