Implementation of a Gamified Puzzle Based on Pro-origami Protein Structure Cartoons: an Experience in Virtual Reality

The use of technology in the classroom enhances the learning process of students. In biology, several complex processes cannot be explained in an easy way in the classroom or in a wet laboratory experience. One alternative to this issue is the use of in silicon simulations. The Pro-origami software allows users to represent complex protein fold structures using 2D topology diagrams. This makes it easier to understand the role of 3D structures in the function of a protein or in a drug interaction. This 2D representation can be the base for the development of an interactive experience for undergraduate students to understand complex interactions between proteins and other molecules. We developed a virtual reality experience with game concepts for the HTC VIVE device designed for students, allowing them to participate in the building of protein folds using the topology representation for several main proteins (e.g. HIV). To test the software, we performed usability tests with 8 Bioinformatic students in order to evaluate the usability and user experience. The results indicate that the virtual reality platform is effective and efficient, and it helps for an easy understanding of complex protein structures.