Does a Coronary Artery Disease Polygenic Risk Score (CAD PRS) improve risk prediction and identification for statin therapy in primary prevention patients?
A CAD PRS has greater predictive utility in younger individuals and helps identify borderline or intermediate risk patients who would benefit from statin therapy in primary prevention.
Results of this cohort study suggest that the predictive ability of a CAD PRS was greater in younger individuals and can be used to better identify patients with borderline and intermediate clinical risk who should initiate statin therapy.
Marston et al. (Wed,) studied this question.