Why the study?
Do candesartan and telmisartan improve neurorestoration and cognitive outcomes in a mouse model of traumatic brain injury?
Population
Mouse model of controlled cortical impact injury (traumatic brain injury) and AT1R knockout mice
Comparison
Candesartan and telmisartan vs Control/vehicle (implied for preclinical model)
Design
Preclinical
Follow-up
Up to 30 days
Authors
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Cautions against clinical use after TBI; leaves open translation of PPARγ-mediated effects to human trials.
Do candesartan and telmisartan improve neurorestoration and cognitive outcomes in a mouse model of traumatic brain injury?
Sartans with dual AT1R blocking and PPARγ activating properties, such as candesartan, show therapeutic potential for neurorestoration after traumatic brain injury in preclinical models.
Villapol et al. (2015) studied this question.
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