⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

April 14, 2015Borderline Personality Disorder and Emotion DysregulationOpen Access

New-born females show higher stress- and genotype-independent methylation of SLC6A4 than males

Helene Dukal Josef Frank Maren Lang Jens Treutlein Maria Gilles Isabell Wolf Bertram Krumm Renaud Massart Moshe Szyf Manfred Laucht Michael Deuschle Marcella Rietschel Stephanie H. Witt

View Full Paper

Ask AI

Bookmark

Share

Abstract

The present data suggest that sex-specific methylation of SLC6A4 is present at birth, and is independent of early life stress and 5-HTTLPR genotype. This may contribute to the sex-specific prevalence of depression.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Dukal et al. (2015) studied this question.

synapsesocial.com/papers/69d84edb8cb8f39931ae2e0c https://doi.org/10.1186/s40479-015-0029-6

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Review : Serotonin Transporter and Psychiatric Disorders: Listening to the GeneReview · 1998 · 32 citations
2Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Regioncross-sectional · 1996 · 5,164 citations
3Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT GeneCohort Study · 2003 · 8,121 citations
4Association Between Promoter Methylation of Serotonin Transporter Gene and Depressive SymptomsOriginal Research · 2013 · 127 citations
5The relationship of <i>5HTT</i> (<i>SLC6A4</i>) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption StudiesOriginal Research · 2007 · 300 citations

More related papers

Methylation at 5HTT Mediates the Impact of Child Sex Abuse on Women's Antisocial Behavior: An Examination of the Iowa Adoptee Sample2010
Effects of Genotype and Child Abuse on DNA Methylation and Gene Expression at the Serotonin Transporter2012
Peripheral SLC6A4 DNA Methylation Is Associated with In Vivo Measures of Human Brain Serotonin Synthesis and Childhood Physical Aggression2012

More from Borderline Personality Disorder and Emotion Dysregulation

Dimensions of non-suicidal self-injury in suicidal adolescents: the differential role of personality pathology and suicidal ideationFri,
Intimacy in pathological narcissism: a narrative reviewSat,