Why the study?
Is increasing systolic blood pressure within the normal range associated with increased risk of coronary artery calcium and incident ASCVD in individuals without traditional risk factors?
Is increasing systolic blood pressure within the normal range associated with increased risk of coronary artery calcium and incident ASCVD in individuals without traditional risk factors?
Even within ranges traditionally considered normal (starting at 90 mm Hg), increasing systolic blood pressure is associated with a graded increase in ASCVD risk, highlighting the importance of primordial prevention.
Answers are grounded in this paper and cite their sources.
Supports primordial prevention below current SBP targets; leaves open whether lowering SBP within normal range reduces CAC or ASCVD events.
Beginning at an SBP level as low as 90 mm Hg, there appears to be a stepwise increase in the presence of coronary artery calcium and the risk of incident ASCVD with increasing SBP levels. These results highlight the importance of primordial prevention for SBP level increase and other traditional ASCVD risk factors, which generally seem to have similar trajectories of graded increase in risk within values traditionally considered to be normal.
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Whelton et al. (2020) studied this question.
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