Answers are grounded in this paper and cite their sources.
TGF-β1, TGF-β2 and TGF-β3 promote migration of NIH-OVCAR3 ovarian cancer cells independently of cell proliferation and without conversion to a complete EMT phenotype. Epithelial ovarian cancer commonly metastasis to the surrounding tissue or inside the peritoneum rather than invading blood vessels to set distance metastasis. Our result raises the question whether ovarian cancer primarily spread via collective migration than via single cell invasion.
No takes yet. Share an insight, caveat, or question.
Gao et al. (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: