Why the study?
Does renin inhibition reduce cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis in diabetic rats compared to ARBs and ACE inhibitors?
Does renin inhibition reduce cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis in diabetic rats compared to ARBs and ACE inhibitors?
In a diabetic rat model, renin inhibition appears more effective than ARBs and ACE inhibitors at mitigating cardiac intracellular RAS-mediated oxidative stress and fibrosis.
Does not support clinical use of renin inhibition over ARBs or ACE inhibitors; hypothesis-generating for diabetic cardiomyopathy in humans.
Diabetes activates the cardiac intracellular RAS, which increases oxidative stress and cardiac fibrosis. Renin inhibition has a more pronounced effect than ARBs and ACE inhibitors on these diabetes complications and may be clinically more efficacious.
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Singh et al. (2008) studied this question.
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