Does renin inhibition reduce cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis in diabetic rats compared to ARBs and ACE inhibitors?
In a diabetic rat model, renin inhibition appears more effective than ARBs and ACE inhibitors at mitigating cardiac intracellular RAS-mediated oxidative stress and fibrosis.
Diabetes activates the cardiac intracellular RAS, which increases oxidative stress and cardiac fibrosis. Renin inhibition has a more pronounced effect than ARBs and ACE inhibitors on these diabetes complications and may be clinically more efficacious.
Singh et al. (Thu,) studied this question.