Key result
Metastatic primary hepatic Ewing's sarcoma in a 7-year-old boy marks the youngest case described to date.
Why the study?
Ewing sarcoma exceptionally originates in visceral organs, and primary hepatic presentations are extremely rare.
Case Report (n=1)
No
Reports the youngest known case of primary hepatic Ewing's sarcoma, highlighting the need to consider it in pediatric liver tumor differential diagnosis.
Primary hepatic Ewing sarcoma should enter the pediatric liver tumor differential at any age; extends the known spectrum for this rare entity.
Ewing’s sarcoma (ES) is a rare malignant small round-cell tumor that usually arises in bone and only exceptionally originates in visceral organs. We report the case of a 7-year-old boy with primary hepatic ES, the youngest case described to date. Imaging revealed a large, solid hepatic mass with heterogeneous enhancement and extensive local vascular involvement, associated with pulmonary and skeletal metastases. Histology and immunohistochemistry (CD99 +, INI-1 +, NKX2.2 +, Ki-67 ≈ 60%) confirmed the diagnosis. This is the first Moroccan and the seventh case of primary hepatic ES reported in the literature, emphasizing the need to consider this entity in the differential diagnosis of pediatric liver tumors.
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Lembarki et al. (2026) conducted a case report in Primary hepatic Ewing's sarcoma (n=1). Primary hepatic Ewing's sarcoma was diagnosed in a 7-year-old boy with pulmonary and skeletal metastases, representing the youngest case described to date.
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