Mechanoredox Radical Annulation for the Solvent-Free Synthesis of 2-Substituted Benzothiophenes

Ji Ho Song; Eunsil Kim; Kang Do Hyun; Ji Young Hyun; Hwan Jung Lim; Seong Jun Park

doi:10.1039/d6mr00013d

January 1, 2026RSC MechanochemistryOpen Access

Mechanoredox Radical Annulation for the Solvent-Free Synthesis of 2-Substituted Benzothiophenes

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Key Points

The aim is to synthesize 2-substituted benzothiophenes using mechanoredox radical annulation.
Utilized ball-milling for the reaction process
Employed 2-(methylthio)benzenediazonium salts and alkynes as reactants
Achieved synthesis without need for solvent, photoredox, or electrochemical systems
Successfully produced 2-substituted benzothiophenes through radical annulation
Showed effective single-electron transfer driven by mechanical energy

Implication

Mechanoredox-enabled annulation produces 2-substituted benzothiophenes, suggesting a new solvent-free method.

Abstract

A mechanoredox-enabled radical annulation under ball-milling conditions affords 2-substituted benzothiophenes 3 from 2-(methylthio)benzenediazonium salts 1 and alkynes 2 . Mechanical energy drives single-electron transfer without photoredox or electrochemical systems, providing a...

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Cite This Study

Song et al. (2026) studied this question.

synapsesocial.com/papers/69d893a86c1944d70ce04a4c https://doi.org/10.1039/d6mr00013d

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Mechanoredox Radical Annulation for the Solvent-Free Synthesis of 2-Substituted Benzothiophenes

Key Points

Implication

Abstract

Discussion

Cite This Study

Mechanoredox Radical Annulation for the Solvent-Free Synthesis of 2-Substituted Benzothiophenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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