Molecular Characterization of the Effect of Glucagon-Like Peptide-1 Receptor Agonist Semaglutide in the Nephrotoxic Serum Nephritis Mouse Model | Synapse
April 10, 2026Open Access
Molecular Characterization of the Effect of Glucagon-Like Peptide-1 Receptor Agonist Semaglutide in the Nephrotoxic Serum Nephritis Mouse Model
Key Points
This research aims to investigate the effects of semaglutide on nephrotoxic serum nephritis models related to chronic kidney disease.
Utilized a nephrotoxic serum nephritis mouse model.
Administered semaglutide treatment to the rodents.
Assessed kidney function and related molecular pathways.
Semaglutide exhibited beneficial effects on kidney function.
These effects were independent of its roles in weight loss or blood sugar control.
Abstract
These findings demonstrate that the beneficial effects of semaglutide treatment in this rodent model of CKD can occur separately from its anti-obesity and anti-diabetes effects.