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Symptomatic Methemoglobinemia at Low Levels in a Patient With Obstructive Sleep Apnea | Synapse

April 10, 2026Open Access

Symptomatic Methemoglobinemia at Low Levels in a Patient With Obstructive Sleep Apnea

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Key Points

To describe an unusual case of symptomatic methemoglobinemia at low levels secondary to dapsone use.
Case report of a 66-year-old man
Documented symptoms of dyspnea and hypoxia
Measured methemoglobin percentage less than 10%
Methemoglobinemia caused hypoxemia despite low methemoglobin percentage
Patient had obstructive sleep apnea
Reveals potential risks of dapsone use in certain individuals

Abstract

Previously reported cases of hypoxemia secondary to methemoglobinemia usually had measured methemoglobin percentages of around 20% or greater. We report an unusual case of methemoglobinemia secondary to dapsone use in a 66-year-old man with obstructive sleep apnea who presented with dyspnea and hypoxia with a methemoglobin percentage of less than 10%.

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Authors

D

DON MATHEW

R

Rachel E. Powell

University of Pittsburgh

Journals

A

Annals of Internal Medicine Clinical Cases

Actions

Institutions

University of Pittsburgh

University of Pittsburgh Medical Center

References and Citations

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Cite this study

MATHEW et al. (Wed,) studied this question.

synapsesocial.com/papers/69d894326c1944d70ce051c1 — DOI: https://doi.org/10.7326/aimcc.2025.1176