Expression of concern highlights issues with images in a study on p53 stabilization in cancer biology, suggesting reliability concerns.
Expression of Concern: The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination The PLOS One Editors After this article [1] was published, concerns were raised regarding Figs 1 and S7.Specifically, In Fig 1C, there appear to be vertical discontinuities between the ING1a and + LC lanes of the Cyclin D1 and Ub panels. In Fig 1D, the ING1b + P53 and ING1b lanes of the Cyclin D1 panel appear to be discontinuous with the adjacent background.
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