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April 10, 2026Journal of Perinatology3 citationsOpen Access

Revisiting time to blood culture positivity: can we decrease antibiotic exposure in the NICU?

RGRachel J. GrafAEAmy M. EdwardsMCMoira Crowley

Key Points

  • The research aims to assess whether discontinuing empiric antibiotics at 24 hours can be justified based on blood culture positivity rates.
  • Analyzed blood culture positivity data in a NICU setting.
  • Evaluated the impact of antibiotic exposure on patient outcomes.
  • Set an a priori target of 90% positivity for adjusting antibiotic practices.
  • Failed to meet the target of 90% blood culture positivity after 24 hours.
  • Results do not support the cessation of empiric antibiotics at this timeframe.
  • Highlights the need for individualized evaluation of NICU data before changing practices.

Abstract

Our data do not support discontinuing empiric antibiotics at 24 h as our a priori target of 90% positivity was not met. These results underline the importance of evaluating an individual NICU's data before implementing a practice change.

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Cite This Study

Graf et al. (2026) studied this question.

synapsesocial.com/papers/69d8946e6c1944d70ce055echttps://doi.org/10.1038/s41372-026-02629-6
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