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April 7, 2026Journal of Oral Pathology and MedicineOpen Access

Dual Beneficial Effects of Topical l ‐Glutamine on Oral Mucositis in 5‐Fluorouracil‐Treated Mice

Juliana Francisca Grossi Heleno Igor de Campos Fontes Letícia Cristine Cardoso dos Santos Vinícius R. Campos Iury Berckmann Freitas Gomes Derek William Gilroy Silvia Passos Andrade Paula Peixoto Campos

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Key Points

This research aims to explore the effects of topical l-glutamine on oral mucositis in mice treated with 5-fluorouracil.
Topical application of l-glutamine was used
Mice were treated with 5-fluorouracil to induce oral mucositis
Inflammation and tissue remodeling were assessed
L-glutamine reduced inflammation related to oral mucositis
Improved tissue remodeling was observed in treated mice
The treatment showed a dual beneficial effect on mucositis symptoms

Implication

Experimental treatment shows benefits for oral mucositis in immunosuppressed mice, suggesting potential for improved care.

Abstract

Topical application of l-glutamine acted on multiple axes of OM, modulating inflammation and tissue remodeling in immunosuppressed mice.

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Cite This Study

Heleno et al. (2026) studied this question.

synapsesocial.com/papers/69d8948f6c1944d70ce05818 https://doi.org/10.1111/jop.70135

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1L‐Glutamine Substantially Improves 5‐Fluorouracil‐Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice2024 · 20 citations
2Comparative preventive effects of probiotic and postbiotic preparations of <i>Lacticaseibacillus rhamnosus</i> L156.4 and GG in a 5-FU-induced mucositis modelOriginal Research · 2026
3Mitigation of chemotherapy-induced experimental intestinal mucositis through postbiotic lactateOriginal Research · 2024 · 4 citations
4A Probiotic Combination of <i>Limosilactobacillus reuteri</i> and <i>Clostridium butyricum</i> Ameliorates 5‐Fluorouracil‐Induced Intestinal Mucositis in Rats by Strengthening Barrier Integrity and Modulating Immuno‐Microbial HomeostasisOriginal Research · 2026 · 1 citations
5Protective role of Probiatop® in mitigating 5-fluorouracil-induced intestinal mucositis in miceOriginal Research · 2026 · 1 citations

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Nutritional Amino Acid Supplementation Reduces Severity and Enhances Recovery of Radiation‐Induced Oral Mucositis: A Triple‐Blind Randomized Clinical Trial2026

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