Examines how platelet-leukocyte interactions drive metastasis and highlights new therapeutic approaches to target these pathways.
Highlights1. Platelet-leukocyte crosstalk promotes CTC survival, immune evasion, and pre-metastatic niche priming.2. NETosis facilitates metastatic progression by trapping CTCs and remodeling the extracellular matrix.3. Conventional anti-platelet and anti-inflammatory therapies incompletely target these interconnected pathways.4. Multi-stimuli-responsive nanoparticles and functionalized hydrogels allow spatiotemporally precise delivery of cytotoxic, anti-platelet, and immunomodulatory agents.5. Multi-modal network disruption integrates platelet, immune, and tumor targeting to limit metastatic seeding and disease progression.
No takes yet. Share an insight, caveat, or question.
Naghinezhad et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: