Targeting the Hedgehog Signaling Pathway in the Retina Using Quercetin-Loaded Lipid Nanoparticles for Myopia Control

Key Points

• The aim is to explore the effectiveness of quercetin-loaded lipid nanoparticles in targeting the hedgehog signaling pathway for myopia control in the retina.
• Utilized quercetin-loaded lipid nanoparticles (QLSs) for retinal application.
• Evaluated aqueous solubility and bioavailability of QLSs.
• Assessed dose-response efficacy for myopia control.
• QLSs showed excellent aqueous solubility.
• Significant efficacy observed with low-dose administration.
• Promising implications for clinical applications in myopia treatment.

Abstract