Olink Proteomics Reveals CCL2 Aggravates Perihematomal Edema After Intracerebral Hemorrhage in High‐Altitude Migrants Via CCR2 / NF ‐ κB ‐Mediated Blood–Brain Barrier Disruption

R. Stephanie Huang; Ling Gao; Yalan Dai; Shangshi Li; Jiancai Guru; Mingxi Li; Yuanyuan Chen; Bo Wu; Xufang Ru; Qing Gong; Jun Tang; Gang Zhu; Yujie Chen

doi:10.1002/cns.70868

April 1, 2026CNS Neuroscience & TherapeuticsOpen Access

Olink Proteomics Reveals CCL2 Aggravates Perihematomal Edema After Intracerebral Hemorrhage in High‐Altitude Migrants Via CCR2 / NF ‐ κB ‐Mediated Blood–Brain Barrier Disruption

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Key Points

The research aims to investigate how CCL2 contributes to secondary injury following intracerebral hemorrhage at high altitudes.
Utilized Olink proteomics to analyze protein levels and pathways involved in edema
Focused on the CCL2-CCR2-NF-κB signaling pathway
Examined the role of CCL2 in inflammation and blood-brain barrier integrity
CCL2 significantly amplifies inflammation following intracerebral hemorrhage
Activation of the CCR2-NF-κB pathway leads to blood-brain barrier disruption
CCL2 may serve as a potential therapeutic target to reduce secondary injury

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Implication

Olink proteomics demonstrates CCL2 exacerbates edema in high-altitude migrants, indicating possible treatment targets.

Abstract

CCL2 plays an important role in secondary injury after high-altitude ICH, mainly by amplifying inflammation and exacerbating damage via the CCL2-CCR2-NF-κB pathway and may serve as a potential therapeutic target.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69d894ce6c1944d70ce05c89 https://doi.org/10.1002/cns.70868

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Olink Proteomics Reveals CCL2 Aggravates Perihematomal Edema After Intracerebral Hemorrhage in High‐Altitude Migrants Via CCR2 / NF ‐ κB ‐Mediated Blood–Brain Barrier Disruption

Key Points

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Implication

Abstract

Discussion

Cite This Study

Olink Proteomics Reveals CCL2 Aggravates Perihematomal Edema After Intracerebral Hemorrhage in High‐Altitude Migrants Via CCR2 / NF ‐ κB ‐Mediated Blood–Brain Barrier Disruption

Key Points

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Implication

Abstract

Discussion

Cite This Study

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