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April 10, 2026Clinical Laboratory0 citations

Concurrent Macro-Aspartate Aminotransferase Diagnosis: Pregnant and Elderly Cases

XZXiaoyan ZhangJHJiehua Han

Key Points

  • To evaluate the relevance of macro-AST in asymptomatic patients with isolated AST elevation.
  • Analyzed cases of asymptomatic patients with isolated AST elevation.
  • Utilized PEG precipitation as a diagnostic tool.
  • Examined communication practices between clinicians and laboratories.
  • Macro-AST was frequently identified in asymptomatic patients.
  • PEG precipitation proved to be a reliable diagnostic method.
  • Enhanced communication reduced unnecessary testing.

Abstract

Macro-AST should be considered in asymptomatic patients with isolated AST elevation. PEG precipitation is a simple, reliable diagnostic tool. Effective communication between clinicians and laboratories is crucial to avoid unnecessary investigations.

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69d894ec6c1944d70ce05e39https://doi.org/10.7754/clin.lab.2025.250608
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unexplained Isolated AST Elevation: A Case of Macro-AST and a Brief Review of Literature2026
  2. 2Macro-Aspartate Aminotransferase Elevation in a Patient with Chronic Hepatitis B2026
  3. 3The phenomenon of an isolated increase in aspartate transaminase (AST) in a 12-month-old child: pathogenetic mechanisms, patient management tactics2025
  4. 4A-111 “Activation” Of macro-ast by pyridoxal phosphate supplementation2024
  5. 5Elevated maternal serum aminotransferase in early pregnancy associated with early-onset preeclampsia: A cohort study of 116,967 pregnancies in Shanghai, China2025 · 2 citations