Does prenatal exposure to SSRIs increase the risk of persistent pulmonary hypertension of the newborn?
Late pregnancy exposure to SSRIs is associated with a statistically significant but clinically low absolute risk of persistent pulmonary hypertension of the newborn.
The risk of persistent pulmonary hypertension of the newborn seems to be increased for infants exposed to SSRIs in late pregnancy, independent of the potential moderator variables examined. A significant relation for exposure to SSRIs in early pregnancy was not evident. Although the statistical association was significant, clinically the absolute risk of persistent pulmonary hypertension of the newborn remained low even in the context of late exposure to SSRIs.
Grigoriadis et al. (Tue,) studied this question.