Describes the concepts of the integrated stress response to tissue trauma and potential therapeutic interventions to modulate it in perioperative medicine.
May identify perioperative targets for stress modulation; leaves open clinical efficacy pending trials.
The integrated stress response to tissue trauma is crucial for the maintenance of homeostasis. An exaggerated or prolonged response may be detrimental in compromised patients. Knowledge of the involved afferent pathways will suggest therapeutic interventions that may modulate the intensity of the stress response. Described are these concepts as they relate to perioperative medicine.
No takes yet. Share an insight, caveat, or question.
Epstein et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: