Experimental findings show chemotherapy promoting cancer cell spread in melanoma, suggesting implications for treatment outcomes.
Taken together, dacarbazine and the miR-204-5p mimic favor the dissemination of B16 melanoma cells in the lungs, which may support further metastatic development. Although miR-204-5p has been described as a tumor-suppressive microRNA in melanoma, the application of a synthetic mimic to overexpress it in distant organs promoted tumor cell dissemination.
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Lapkina et al. (2026) studied this question.
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