Platelet‐Rich Plasma Injections for the Treatment of Rotator Cuff Pathology Have Higher Complication Rates of Adhesive Capsulitis than Alternative Injectable Therapies: A Systematic Review and Meta‐analysis of Randomized Controlled Trials

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Key Points

This study aims to examine complication rates associated with platelet-rich plasma injections compared to alternative therapies in treating rotator cuff pathology.
Conducted a systematic review of Level I and II randomized-controlled trials
Analyzed complication rates of platelet-rich plasma and alternative injectable therapies
Utilized a meta-analysis approach to evaluate data from multiple studies
Platelet-rich plasma injections showed higher rates of adhesive capsulitis compared to alternative therapies
Certain alternative therapies demonstrated fewer complications
Findings suggest reconsideration of PRP use for rotator cuff conditions due to complication risk

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Systematic review explores complication rates of injectable therapies for rotator cuff pathology, implying higher risks for PRP.

Level II, systematic review and meta-analysis of Level I and II randomized-controlled trials.

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Driscoll et al. (2026) studied this question.

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