Multicolor STED Imaging of Cells and Extracellular Vesicles using Xanthene-conjugated Polymer Dots

Peixiang Li; Kun Tang; Yachen Ying; Long Chen; Qin Shentu; Yating Xiao; Lubin Qi; Ren Cai; Qiongzheng Hu; Jiantao Ping; Xiefan Fang; Yifei Jiang

doi:10.1039/d6tb00345a

January 1, 2026Journal of Materials Chemistry B

Multicolor STED Imaging of Cells and Extracellular Vesicles using Xanthene-conjugated Polymer Dots

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Key Points

To improve STED imaging using high-quality fluorescent probes for better visualization of cells and extracellular vesicles.
Utilized xanthene-conjugated polymer dots as fluorescent probes
Employed multichannel STED nanoscopy for imaging
Focused on comparing imaging performance with traditional probes
Demonstrated enhanced resolution in imaging cellular structures
Showed improved detection of extracellular vesicles
Indicated the effectiveness of xanthene-conjugated polymers in multicolor imaging

Implication

Nanoscopic imaging reveals cellular details in extracellular vesicles, suggesting enhanced imaging capabilities with polymer dots.

Abstract

Stimulated emission depletion (STED) nanoscopy enables imaging beyond the optical diffraction limit. However, its performance critically depends on the quality of fluorescent probes. In particular, multichannel STED imaging imposes stringent...

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69d895206c1944d70ce06296 https://doi.org/10.1039/d6tb00345a

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Multicolor STED Imaging of Cells and Extracellular Vesicles using Xanthene-conjugated Polymer Dots

Key Points

Implication

Abstract

Discussion

Cite This Study

Multicolor STED Imaging of Cells and Extracellular Vesicles using Xanthene-conjugated Polymer Dots

Key Points

Implication

Abstract

Discussion

Cite This Study

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