A systematic review evaluates sildenafil for improving outcomes in preterm infants with bronchopulmonary dysplasia-associated pulmonary hypertension, indicating a research gap.
Evidence to support the use of sildenafil treatment for preterm infants with BPD-PH to improve mortality and morbidity is lacking. More research, particularly randomized controlled trials, on the efficacy and safety of sildenafil treatment for preterm BPD-PH infants is needed.
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Katayama et al. (2026) studied this question.
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