Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class

Johannes Schrittwieser; Andreas Reitner; Karl Kircher; Martin Bertich; Christoph Stapf; Stephanie V Lilja; Amina Paquay; Gregor S. Reiter; Reginald E. Bittner; Wolfgang M. Schmidt; Berthold Pemp

doi:10.1167/iovs.67.4.13

April 7, 2026Investigative Ophthalmology & Visual ScienceOpen Access

Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class

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Key Points

To evaluate how thinning of the inner retinal layer affects visual function in individuals with OPA1-related autosomal dominant optic atrophy (ADOA).
Analyzed the relationship between inner retinal layer thickness and visual acuity (VA) in ADOA patients.
Measured mGCL (macular ganglion cell layer) thickness in the PMB (parafoveal macular bag) subfield.
Considered patient age and genetic variant types as influencing factors.
Significant association found between inner retinal layer thickness and severity of visual acuity and central scotoma.
mGCL thickness was a key predictor of visual function changes.
Worse visual outcomes noted in heterozygous individuals with missense variants in OPA1.

Implication

Shows associations between retinal layer thickness and visual function in OPA1-related optic atrophy, suggesting age and genetic factors influence outcomes.

Abstract

VA and central scotoma severity in OPA1-related ADOA are significantly associated with inner retinal layer thickness, which is impacted by patient age. The mGCL thickness and sensitivity in the PMB subfield were the most indicative clinical parameters for disease-related changes, with worse outcomes in heterozygotes with missense variants in OPA1.

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Cite This Study

Schrittwieser et al. (2026) studied this question.

synapsesocial.com/papers/69d895486c1944d70ce06374 https://doi.org/10.1167/iovs.67.4.13

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Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class

Key Points

Implication

Abstract

Discussion

Cite This Study

Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class

Key Points

Implication

Abstract

Discussion

Cite This Study

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