Why the study?
Does Adipocyte Fatty Acid-Binding Protein (FABP4) suppress cardiomyocyte contraction?
Does Adipocyte Fatty Acid-Binding Protein (FABP4) suppress cardiomyocyte contraction?
FABP4 released from adipocytes may play a mechanistic role in the development of cardiac contractile dysfunction in obesity.
Implicates FABP4 in obesity cardiomyopathy; hypothesis-generating and requires human validation before any clinical consideration.
We conclude that the release of FABP4 from adipocytes may be involved in the development of cardiac contractile dysfunction of obese subjects.
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Lamounier‐Zepter et al. (2009) studied this question.
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