Intrahepatic cholestasis of pregnancy and offspring neurodevelopment: bile acid-mediated mechanisms and long-term neurodevelopmental outcomes

Siyu Dai; Hao Zhao; Yupei Xie; Qian Chen; Qiuhe Chen; Y R Li; Dan Shan; Xin Tan; Yayi Hu

doi:10.1007/s00404-026-08411-5

April 8, 2026Archives of Gynecology and ObstetricsOpen Access

Intrahepatic cholestasis of pregnancy and offspring neurodevelopment: bile acid-mediated mechanisms and long-term neurodevelopmental outcomes

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Key Points

This research aims to explore the potential long-term neurodevelopmental effects of intrahepatic cholestasis of pregnancy in offspring through bile acid-mediated mechanisms.
Assessment of maternal bile acid levels during pregnancy.
Evaluation of placental function and dysfunction.
Longitudinal tracking of child neurodevelopmental outcomes.
Refinement of exposure assessment methods.
Evidence suggests maternal bile acids may contribute to neurodevelopmental risks in offspring.
Identified mechanisms link placental dysfunction with neurodevelopmental outcomes.
Emphasizes the need for further longitudinal studies to clarify these associations.

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Implication

Observational study investigates neurodevelopmental effects in offspring from maternofetal bile acid exposure, suggesting implications for long-term development.

Abstract

Current evidence supports a life-course perspective on ICP beyond established perinatal risks. Maternal bile acids and placental dysfunction provide a coherent mechanistic framework for possible neurodevelopmental effects, but pregnancy-relevant mechanistic studies and longitudinal cohorts with refined exposure assessment are still needed.

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Cite This Study

Dai et al. (2026) studied this question.

synapsesocial.com/papers/69d895796c1944d70ce067ff https://doi.org/10.1007/s00404-026-08411-5

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Intrahepatic cholestasis of pregnancy and offspring neurodevelopment: bile acid-mediated mechanisms and long-term neurodevelopmental outcomes

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Intrahepatic cholestasis of pregnancy and offspring neurodevelopment: bile acid-mediated mechanisms and long-term neurodevelopmental outcomes

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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