Demonstrates how inhibiting bilirubin affects liver injury in obstructive cholestasis, suggesting critical antioxidant roles for bilirubin.
The inhibition of HO1 and consequent decrease in the endogenous levels of BR negatively impacts the outcome of obstructive cholestasis due to the loss of BR's antioxidant and cytoprotective effects. BR accumulation during cholestasis serves as a critical defence against oxidative damage induced by retained bile salts.
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Martín et al. (2026) studied this question.
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