Intervention of hIAPP amyloid aggregation by smart posttransmuting anti-amyloidogenic peptidomimetics

Altaf Hussain Kawa; Biswadeepak Satapathy; Shinjini Bhattacharya; Sachin Kumar; Bhubaneswar Mandal

doi:10.1039/d5tb02851e

January 1, 2026Journal of Materials Chemistry B

Intervention of hIAPP amyloid aggregation by smart posttransmuting anti-amyloidogenic peptidomimetics

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Key Points

The research aims to explore innovative peptidomimetics that can prevent the aggregation of hIAPP, linking this process to T2DM.
Investigated various peptidomimetics for their effects on hIAPP aggregation.
Utilized in vitro models to simulate amyloid formation.
Analyzed the efficacy of selected compounds on amyloid suppression.
Certain peptidomimetics demonstrated a significant reduction in hIAPP aggregation.
The findings suggest a promising avenue for therapeutic intervention in T2DM.

Implication

Intervention aims to reduce amyloid aggregation in type 2 diabetes, suggesting a potential therapeutic pathway.

Abstract

hIAPP, human islet amyloid polypeptide, aggregates have been implicated in the development of type 2 diabetes mellitus (T2DM). As a prelude to developing a potential cure for T2DM, researchers worldwide...

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Cite This Study

Kawa et al. (2026) studied this question.

synapsesocial.com/papers/69d895a86c1944d70ce06c32 https://doi.org/10.1039/d5tb02851e

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Intervention of hIAPP amyloid aggregation by smart posttransmuting anti-amyloidogenic peptidomimetics

Key Points

Implication

Abstract

Discussion

Cite This Study

Intervention of hIAPP amyloid aggregation by smart posttransmuting anti-amyloidogenic peptidomimetics

Key Points

Implication

Abstract

Discussion

Cite This Study

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