Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Kondaiah Palsa; Swetapadma Sahu; David B. Rye; Lynn Marie Trotti; Irina Elcheva; Vladimir S. Spiegelman; James R. Connor

doi:10.1002/ana.78221

April 7, 2026Annals of NeurologyOpen Access

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

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Key Points

This research investigates how cerebrospinal fluid from restless legs syndrome patients affects iron uptake in endothelial cells of the blood-brain barrier.
Treatment of endothelial cells with cerebrospinal fluid from restless legs syndrome patients.
Measurement of transferrin receptor 1 (TfR1) expression levels.
Analysis of miR-124-3p levels and their effect on mRNA stability.
Endothelial cells exhibit signs of iron deficiency when treated with cerebrospinal fluid from RLS patients.
TfR1 protein expression does not increase as expected, indicating a disruption in regulation.
Increased levels of miR-124-3p contribute to reduced TfR1 mRNA stability.

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Implication

Findings reveal that cerebrospinal fluid from restless legs syndrome patients disrupts iron uptake in endothelial cells, suggesting potential pathophysiological mechanisms.

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Palsa et al. (2026) studied this question.

synapsesocial.com/papers/69d895d86c1944d70ce06fa4 https://doi.org/10.1002/ana.78221

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Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Key Points

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Implication

Abstract

Discussion

Cite This Study

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Key Points

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Implication

Abstract

Discussion

Cite This Study

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