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April 10, 2026Alimentary Pharmacology & Therapeutics4 citations

Dynamics of Circulatory HBcrAg and HBsAg After Nucleos(t)ide Analogue Cessation Using iTACT Assays to Predict Clinical Flares and HBsAg Loss

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YTYing‐Nan TsaiJWJia‐Ling WuCTCheng‐Hao Tseng

Key Points

  • This research aims to explore how the dynamics of HBcrAg and HBsAg can predict clinical flare-ups and HBsAg loss after the discontinuation of nucleos(t)ide analogues.
  • Analyzed HBcrAg and HBsAg levels using iTACT assays.
  • Compared the predictive abilities of HBcrAg and HBsAg dynamics post-nucleoside analogue treatment cessation.
  • Investigated the biological mechanisms associated with HBcrAg and HBsAg production.
  • HBcrAg dynamics more accurately predicted clinical flares.
  • HBsAg dynamics were better at predicting HBsAg loss.
  • Findings support the complementary roles of both biomarkers in clinical practice.

Abstract

HBcrAg dynamics more accurately predict CF, while HBsAg dynamics better predict HBsAg loss after NA cessation, supporting their complementary roles in clinical practice and suggesting distinct biological mechanisms underlying their production.

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Cite This Study

Tsai et al. (2026) studied this question.

synapsesocial.com/papers/69d896046c1944d70ce07289https://doi.org/10.1111/apt.70658
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