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April 10, 2026Annual Review of Biochemistry

Shaping of the Infant Gut Microbiome by Milk Oligosaccharides

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Authors

VFVictoria A. FedericoDCDavid E. CliffelJGJennifer A. Gaddy

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Overview

This review discusses how human milk oligosaccharides shape the gut microbiome in infants, indicating their importance in health.

Key Points

  • The review aims to analyze how human milk oligosaccharides influence the infant gut microbiome and health.
  • Targeted review of existing literature on human milk oligosaccharides and their effects on gut microbiota.
  • Characterization of the roles of HMOs in supporting bacterial and viral gut members.
  • Evaluation of the impact of HMOs on microbial dysbiosis and overall infant gut health.
  • HMOs significantly support the growth of beneficial bacteria in the infant gut.
  • Metabolism of HMOs leads to the production of short-chain fatty acids that enhance gut health.
  • HMOs help prevent microbial dysbiosis, promoting a healthy gut microbiota composition.

Cite This Study

Federico et al. (2026) studied this question.

synapsesocial.com/papers/69d8967d6c1944d70ce07f87https://doi.org/10.1146/annurev-biochem-051024-062915
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