May 31, 2007Journal of Biological ChemistryOpen Access

Short-term Treatment of RAW264.7 Macrophages with Adiponectin Increases Tumor Necrosis Factor-α (TNF-α) Expression via ERK1/2 Activation and Egr-1 Expression

View Full Paper

Ask AI

Bookmark

Population

RAW264.7 macrophages

Design

Preclinical

Follow-up

18 h

Authors

PPPil-Hoon ParkYeungnam University MMMegan R. McMullenCleveland Clinic HHHonglian HuangCleveland Clinic

Discussion

Member takes

Implication

Hypothesis-generating for adiponectin in macrophage tolerance; human validation required before any clinical consideration.

Structured PICO

Population

RAW264.7 macrophages

Intervention

Globular adiponectin (gAcrp) treatment for 18 h

Outcome

TNF-alpha expression and productionsurrogate

Adiponectin's anti-inflammatory effects in macrophages are mediated through an initial ERK1/2-dependent increase in TNF-alpha, which drives IL-10 production and subsequent LPS tolerance.

Cite This Study

Park et al. (2007) studied this question.

synapsesocial.com/papers/69d8983c52654bb436d19720 https://doi.org/10.1074/jbc.m701419200

View Full Paper

Ask AI

Bookmark

Short-term Treatment of RAW264.7 Macrophages with Adiponectin Increases Tumor Necrosis Factor-α (TNF-α) Expression via ERK1/2 Activation and Egr-1 Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Short-term Treatment of RAW264.7 Macrophages with Adiponectin Increases Tumor Necrosis Factor-α (TNF-α) Expression via ERK1/2 Activation and Egr-1 Expression

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider