Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

Wei Luo; Yidan Wang; Lin Zhang; Pingping Ren; Chen Zhang; Yanming Li; Alon R. Azares; Michelle Zhang; Guohui Jiao; Ketan B. Ghaghada; Zbigniew Starosolski; Kimal Rajapakshe; Cristian Coarfa; Yumei Li; Rui Chen; Keigi Fujiwara; Jun‐ichi Abe; Joseph S. Coselli; Dianna M. Milewicz; Scott A. LeMaire; Ying H. Shen

doi:10.1161/circulationaha.119.041460

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Abstract

Our findings indicate that the presence of cytosolic DNA and subsequent activation of cytosolic DNA sensing adaptor STING signaling represent a key mechanism in aortic degeneration and that targeting STING may prevent sporadic AAD development.

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Luo et al. (2019) studied this question.

synapsesocial.com/papers/69d89965a5ecc596b5d17cb0 https://doi.org/10.1161/circulationaha.119.041460

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Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

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Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture

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