Single-cell transcriptomic analysis reveals a favorable functional profile in human double-negative T cells, supporting allogeneic adoptive cell therapy for cancer.
These results highlight the unique transcriptional, cellular, and functional profile of human DNTs and support the continued clinical investigation of allogeneic DNT therapy. The data also provide a reference gene signature that may help improve the efficacy of other types of allogeneic adoptive cellular therapies.
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Tin et al. (2025) studied this question.
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