Key result
Primary pulmonary hypertension PASMCs display abnormal growth responses to TGF-beta1 and BMPs.
Why the study?
Altered growth responses of pulmonary artery smooth muscle cells to TGF-beta1 and BMPs may contribute to the pathogenesis of primary pulmonary hypertension.
Altered integration of TGF-beta superfamily growth signals in pulmonary artery smooth muscle cells may contribute to the pathogenesis of primary pulmonary hypertension.
We conclude that PASMCs from patients with PPH exhibit abnormal growth responses to TGF-beta(1) and BMPs and that altered integration of TGF-beta superfamily growth signals may contribute to the pathogenesis of PPH.
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Morrell et al. (2001) studied this question. Pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension show abnormal growth responses to TGF-beta1 and BMPs, potentially contributing to disease pathogenesis.
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