Why the study?
Do patients with infective endocarditis undergoing cardiac surgery have different ROTEM coagulation profiles and bleeding complication rates compared to those without infective endocarditis?
Do patients with infective endocarditis undergoing cardiac surgery have different ROTEM coagulation profiles and bleeding complication rates compared to those without infective endocarditis?
Patients with infective endocarditis undergoing cardiac surgery have altered coagulation profiles detectable by ROTEM and higher bleeding risks, suggesting standard perioperative coagulation algorithms may need adjustment.
May warrant cautious ROTEM-guided management in IE cardiac surgery; leaves open whether adjusted algorithms improve outcomes in trials.
The findings of this exploratory investigation show significantly altered coagulation profiles in patients with infective endocarditis, with concomitant hyper- and hypocoagulability. Furthermore, the incidence of bleeding complications and transfusion requirements were increased in patients with endocarditis. These results show the potential of ROTEM to detect coagulation abnormalities in patients with infective endocarditis. Existing point-of-care coagulation testing guided algorithms for optimizing perioperative coagulation management possibly need to be adjusted for these high-risk patients undergoing cardiac surgery.
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Breel et al. (2023) studied this question.
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