Population
18 female MRL/lpr mice (SLE model) and 18 female BALB/c mice (controls)
Comparison
Assessment of IFIT1 expression vs BALB/c control mice
Design
Preclinical
Authors
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Animal data linking IFIT1 to podocyte injury warrant no clinical change; leaves open validation in human lupus nephritis.
IFIT1 expression is associated with podocyte damage and suppression of essential glomerular filtration proteins in a mouse model of SLE.
Hu et al. (2016) studied this question.
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