The average number of IBA1+ macrophages in submacular and paramacular choroid was significantly higher in early/intermediate AMD compared to that in aged controls. HLA-DR+ submacular macrophages were significantly increased in all stages of AMD, and they were significantly more round and smaller in size in the submacular AMD choroid, suggesting their activation. These findings support the concept that AMD is an inflammatory disease.
No takes yet. Share an insight, caveat, or question.
McLeod et al. (2016) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: