Why the study?
Does altering the IL-1/IL-1Ra balance modulate cardiac remodeling following acute myocardial infarction in mice?
Does altering the IL-1/IL-1Ra balance modulate cardiac remodeling following acute myocardial infarction in mice?
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Modulating the IL-1/IL-1Ra balance at the IL-1R1 level can protect against adverse cardiac remodeling following myocardial infarction in a preclinical mouse model.
An imbalance in IL-1/IL-1Ra signaling at the IL-1R1 level modulates the severity of cardiac remodeling after AMI in the mouse, with reduced IL-1R1 signaling providing protection and unopposed IL-1R1 signaling providing harm.
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Abbate et al. (2011) studied this question.
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