Why the study?
Do statins and thiazolidinediones inhibit TNFα-induced IL-1 or IL-6 expression in human cardiac fibroblasts?
Do statins and thiazolidinediones inhibit TNFα-induced IL-1 or IL-6 expression in human cardiac fibroblasts?
Statins and TZDs do not exert their myocardial anti-inflammatory effects by inhibiting TNFα-induced IL-1 or IL-6 expression in human cardiac fibroblasts.
Animal data rule out fibroblast IL-1/IL-6 inhibition as mechanism; leaves open alternative pathways for statin/TZD myocardial effects.
Our data provide important insights into the regulation of pro-inflammatory cytokine expression in human cardiac fibroblasts and suggest that the myocardial anti-inflammatory effects of statins and TZDs are not due to inhibition of TNFalpha-induced IL-1 or IL-6 expression by cardiac fibroblasts.
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Turner et al. (2007) studied this question.
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